Synthetic pentadecapeptide

BPC-157

Also known as Body Protection Compound 157 · Pentadecapeptide BPC 157 · BPC157 · Bepecin

In cell-based and isolated-tissue models, BPC-157 functions as a modulator of endothelial and fibroblast signaling rather than acting on a single cloned receptor.

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ClassSynthetic pentadecapeptide

Molecular weight1419.5 g/mol (monoisotopic/average ~1419.55)

Molecular formulaC62H98N16O22

CAS number137525-51-0

The overview

What is BPC-157?

In cell-based and isolated-tissue models, BPC-157 functions as a modulator of endothelial and fibroblast signaling rather than acting on a single cloned receptor. In vascular endothelial cells it up-regulates VEGFR2 (KDR) mRNA and protein expression - without raising VEGF-A - and promotes VEGFR2 internalization, driving time-dependent activation of the VEGFR2–Akt–eNOS cascade; these effects are abolished by the endocytosis inhibitor dynasore. A VEGF-independent route engages Src kinase–mediated phosphorylation within the Caveolin-1/eNOS complex, releasing eNOS to increase nitric oxide output and modulate vasomotor tone in a nitric-oxide-dependent manner. In tendon fibroblasts, BPC-157 increases FAK and paxillin phosphorylation, promotes F-actin assembly, and enhances cell spreading and migration. Reported activity spans nanomolar-to-micromolar concentrations in vitro. Reviews frame its broader profile around interaction with the nitric-oxide system. These descriptions are limited to in-vitro and ex-vivo receptor-signaling observations.

In the research

Where BPC-157 shows up

The areas researchers focus on with BPC-157 - and why it has the science community paying attention.

In-vitro angiogenesis signaling (VEGFR2 expression, internalization, and VEGFR2-Akt-eNOS pathway activation in endothelial cells)
Endothelial nitric oxide synthase (eNOS) regulation via the Src-Caveolin-1 axis and ex-vivo vasomotor-tone modulation
Tendon fibroblast cytoskeletal signaling (FAK/paxillin phosphorylation, F-actin assembly, cell migration models)
Nitric-oxide-system interaction as a mechanistic framework in preclinical reviews
Cellular cytoprotection and oxidative-stress (H2O2) survival assays in fibroblast culture

By the numbers

The facts that matter

PubChem CID9941957

Amino acid count15 (pentadecapeptide)

OriginSynthetic peptide representing a partial sequence of the BPC protein found in human gastric juice

Key in-vitro pathwayVEGFR2-Akt-eNOS activation (dynasore-sensitive) in vascular endothelial cells

VEGF-independent NO pathwaySrc-Caveolin-1-eNOS activation modulating vasomotor tone

Regulatory statusNot an FDA-approved drug; research-use peptide

To the molecule

Molecular specifications

Molecular formulaC62H98N16O22

Molecular weight1419.5 g/mol (monoisotopic/average ~1419.55)

CAS number137525-51-0

Amino-acid sequenceGly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (one-letter: GEPPPGKPADDAGLV)

Sourced, not claimed

The science behind it

The peer-reviewed studies behind BPC-157, linked so you can read them yourself.

Chang, C. H., et al. (2014). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules.
DOI ↗
Sikiric, P., Seiwerth, S., et al. (2018). Stable gastric pentadecapeptide BPC 157, G-protein coupled receptor, and angiogenesis. Current Pharmaceutical Design.
DOI ↗

Straight answers

Questions, answered

Is BPC-157 approved by the FDA?

No. BPC-157 is not an FDA-approved drug. We supply it as a research-use-only reference compound, identity-verified for purity with a COA on every vial.

What class of compound is BPC-157?

BPC-157 is classified as: Synthetic pentadecapeptide (15-amino-acid oligopeptide; partial sequence derived from human gastric juice protein BPC); cytoprotective/pro-angiogenic research peptide.

What is the molecular weight of BPC-157?

The molecular weight of BPC-157 is 1419.5 g/mol (monoisotopic/average ~1419.55), with a molecular formula of C62H98N16O22.

What is the CAS number for BPC-157?

The CAS Registry Number for BPC-157 is 137525-51-0.

What is the amino acid sequence of BPC-157?

BPC-157 has the sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (one-letter: GEPPPGKPADDAGLV).

Available now

Get BPC-157

Identity-verified, third-party tested, made in the USA, and traceable to its lot - with a scannable COA on every vial. For research use only.

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Go deeper

More on BPC-157

MechanismBPC-157 mechanism of action: receptor binding, signal transduction, and Read →ResearchBPC-157 research: peer-reviewed studies, in-vitro and preclinical model Read →ReconstitutionHow BPC-157 is reconstituted for in-vitro laboratory research: bacteriosRead →Half-LifeBPC-157 pharmacokinetic, stability, degradation, and storage characterisRead →SpecsBPC-157 molecular specifications: amino-acid sequence, molecular weight,Read →FAQAnswers to common research questions about BPC-157: classification, struRead →

Keep exploring

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For in-vitro laboratory research use only. Not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. BPC-157 is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.

Complete the stack

Researchers often pair BPC-157 with

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GLOW Blend

BPC-157 is one of three peptides in the GLOW research stack - the consolidated repair + dermal kit.

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