CJC-1295 without DAC
Also known as Modified GRF (1-29) · Mod GRF 1-29 · CJC-1295 No DAC · [D-Ala2]-GHRH(1-29)NH2 (tetrasubstituted analog)
In receptor-level studies, this tetrasubstituted GHRH(1-29) amide acts as an agonist at the growth hormone-releasing hormone receptor (GHRH-R), a class B G protein-coupled receptor expressed on pituitary somatotroph cells.
The overview
What is CJC-1295 without DAC?
In receptor-level studies, this tetrasubstituted GHRH(1-29) amide acts as an agonist at the growth hormone-releasing hormone receptor (GHRH-R), a class B G protein-coupled receptor expressed on pituitary somatotroph cells. Ligand binding couples through Gs to activate adenylyl cyclase, raising intracellular cAMP and engaging protein kinase A signaling; in model systems this is associated with downstream calcium influx and somatotroph signaling consistent with GH-axis activation. The four substitutions relative to native GRF(1-29) - D-Ala at position 2, Gln8, Ala15, and Leu27 - are introduced at metabolically labile or oxidation-prone sites; the D-Ala2 substitution in particular confers resistance to dipeptidyl peptidase-IV cleavage, reducing in-vitro/ex-vivo metabolic clearance relative to the unmodified peptide. Unlike the drug-affinity-complex (DAC) variant, the no-DAC form lacks the maleimidopropionyl-Lys30 albumin-binding extension, so it does not form covalent serum-albumin bioconjugates and exhibits comparatively short receptor-occupancy kinetics in experimental models.
In the research
Where CJC-1295 without DAC shows up
The areas researchers focus on with CJC-1295 without DAC - and why it has the science community paying attention.
- GHRH-receptor (class B GPCR) binding and agonist pharmacology in vitro
- Gs/adenylyl cyclase/cAMP/PKA signal transduction in pituitary somatotroph cell models
- Structure-activity relationships of GHRH(1-29) substitution analogs
- Dipeptidyl peptidase-IV (DPP-IV) resistance and peptide metabolic-stability assays
- Comparative receptor-occupancy kinetics of DAC vs no-DAC GHRH analogs in animal/cell models
- GH/IGF-1 axis endocrine-signaling research models
By the numbers
The facts that matter
To the molecule
Molecular specifications
Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (one-letter, C-terminal amide: Y-[D-A]-DAIFTQSYRKVLAQLSARKLLQDILSR-NH2)Sourced, not claimed
The science behind it
The peer-reviewed studies behind CJC-1295 without DAC, linked so you can read them yourself.
- Teichman, S. L., et al. (2006). Prolonged stimulation of growth hormone and IGF-I secretion by CJC-1295. J. Clinical Endocrinology & Metabolism.
- Alba, M., et al. (2005). Once-daily administration of CJC-1295 maintains pulsatile GH secretion. Am. J. Physiology-Endocrinology and Metabolism.
Straight answers
Questions, answered
Is CJC-1295 without DAC approved by the FDA?
No. CJC-1295 without DAC is not an FDA-approved drug. We supply it as a research-use-only reference compound, identity-verified for purity with a COA on every vial.
What class of compound is CJC-1295 without DAC?
CJC-1295 without DAC is classified as: Synthetic growth hormone-releasing hormone (GHRH/GRF) analog; tetrasubstituted GHRH(1-29) amide; growth hormone secretagogue (GHRH-receptor agonist class).
What is the molecular weight of CJC-1295 without DAC?
The molecular weight of CJC-1295 without DAC is 3367.9 g/mol (average; reported as ~3367.95), with a molecular formula of C152H252N44O42.
What is the CAS number for CJC-1295 without DAC?
The CAS Registry Number for CJC-1295 without DAC is 863288-34-0.
What is the amino acid sequence of CJC-1295 without DAC?
CJC-1295 without DAC has the sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 (one-letter, C-terminal amide: Y-[D-A]-DAIFTQSYRKVLAQLSARKLLQDILSR-NH2).
Available now
Get CJC-1295 without DAC
Identity-verified, third-party tested, made in the USA, and traceable to its lot - with a scannable COA on every vial. For research use only.
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For in-vitro laboratory research use only. Not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. CJC-1295 without DAC is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.
Complete the stack
Researchers often pair CJC-1295 No DAC with
Both are GHRH-pathway analogs - the textbook GH-axis sibling pairing, co-discussed in the literature.
GH-axis research is co-modeled with mitochondrial-metabolic research in performance literature.
GH-axis signaling and cellular-energy / longevity research are documented adjacent.