NAD+ Specs: Sequence, MW & CAS
Part of the full NAD+ guide - a pyridine dinucleotide redox coenzyme reference compound, identity-verified with a COA on every vial.
In brief
NAD+ is catalogued in this entry not as a peptide but as a pyridine dinucleotide redox coenzyme and sirtuin/PARP co-substrate - a nucleotide cofactor. Its identity descriptors (formula, mass, CAS, and an explicit "n/a" sequence) reflect that small-molecule classification, and each carries a specific structure-function meaning.
To the molecule
Molecular specifications
The detail
A closer look
01
Why the sequence field reads "n/a"
The sequence is listed as "n/a" because NAD+ is a dinucleotide coenzyme, not an amino-acid chain. There is no peptide primary sequence to report; instead the molecule is defined by its two-nucleotide architecture - an adenine mononucleotide and a nicotinamide mononucleotide joined by a pyrophosphate bridge. The peptideClass field makes this explicit: "not a peptide - a nucleotide cofactor." Functionally, the nicotinamide moiety is the redox-active end that accepts and donates electrons (the chemistry behind the NAD+/NADH couple), while the adenine half anchors enzyme recognition; the pyrophosphate bridge links them into the intact coenzyme.
02
Molecular formula and weight
The molecular formula C21H27N7O14P2 and molecular weight 663.43 g/mol (sourced in the entry to PubChem CID 5892) together encode the full atomic composition: the two phosphorus atoms correspond to the pyrophosphate bridge, the seven nitrogens are distributed across the adenine and nicotinamide rings, and the fourteen oxygens span the two ribose sugars and the phosphate groups. The 663.43 g/mol figure is the conversion factor used in all reconstitution concentration math (moles = mass / 663.43), tying the specs directly to bench preparation.
03
CAS number and structure-function role
The CAS registry number 53-84-9 is the unique chemical identifier for NAD+ as a defined compound, used for reagent sourcing and chain-of-custody. Structure-function links the specs to mechanism: because the nicotinamide ring is redox-active, the same molecule that carries electrons in the NAD+/NADH couple is also the stoichiometric co-substrate cleaved by sirtuins (SIRT1–7), PARPs, and CD38/cADPR enzymes. The dual identity - non-consumptive electron carrier and consumable signaling substrate - is a direct consequence of this dinucleotide structure.
The fine print: products are sold for laboratory research use only and are not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. NAD+ is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.