MOTS-c Specs: Sequence, MW & CAS
Part of the full MOTS-c guide - a mitochondrial-derived peptide reference compound, identity-verified with a COA on every vial.
In brief
MOTS-c carries a compact but information-rich molecular specification, and each field on its spec card maps to a meaningful structure-function detail. It is defined as a mitochondrial-derived peptide (MDP): a 16-residue bioactive microprotein encoded by a short open reading frame within the mitochondrial 12S rRNA (MT-RNR1) gene. Its primary sequence is MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg), its monomer free-peptide molecular weight is 2174.62 g/mol, its molecular formula is C101H152N28O22S2, and it is indexed under CAS Registry Number 1627580-64-6 and PubChem CID 146675088. Together these identifiers fix the molecule's identity for research procurement and characterization. The notes below explain what the sequence, mass, and formula reveal about the peptide's composition and how its structural features relate to the signaling behavior described elsewhere in this reference, using only the data provided in the entry.
To the molecule
Molecular specifications
MRWQEMGYIFYPRKLR (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg)The detail
A closer look
01
Sequence, length, and composition
The 16-residue sequence MRWQEMGYIFYPRKLR is short enough to read directly for compositional cues. It begins with methionine (M), consistent with translation initiation, and contains a second methionine at position six, giving two sulfur-bearing residues that account for the S2 in the molecular formula. There are no cysteine residues, so the peptide has no intramolecular disulfide bonds and exists as a single linear chain. It carries several basic residues, including arginine (R) and lysine (K), notably the C-terminal R-K-L-R cluster, alongside aromatic residues tryptophan (W), tyrosine (Y), and phenylalanine (F). The entry notes the peptide is highly conserved across roughly fourteen mammalian species, with the first approximately eleven residues being especially conserved, suggesting that the N-terminal region is functionally important for the peptide's activity.
02
Molecular weight, formula, and registry identifiers
The stated molecular weight of 2174.62 g/mol is the monomer free-peptide mass and is the constant used for all molar-concentration calculations in research handling. The molecular formula C101H152N28O22S2 enumerates the atom count of the assembled 16-residue chain; the two sulfur atoms correspond to the two methionine residues, and the absence of additional sulfur confirms there are no cysteines. CAS Registry Number 1627580-64-6 and PubChem CID 146675088 provide unambiguous database handles that let researchers cross-reference the exact molecular entity across chemical registries and procurement records. Because these identifiers describe one specific, defined molecule, they distinguish authentic MOTS-c from sequence variants or analogs and serve as the verification anchor when confirming material identity for in-vitro work.
The fine print: products are sold for laboratory research use only and are not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. MOTS-c is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.