Synthetic tuftsin-analogue heptapeptide

Selank

Also known as TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro · tuftsin analogue

Selank is a synthetic heptapeptide built on the natural immunopeptide tuftsin (Thr-Lys-Pro-Arg) by appending a C-terminal Pro-Gly-Pro tripeptide.

Research referenceJump to specs ↓

ClassSynthetic tuftsin-analogue heptapeptide

Molecular weight751.87 g/mol

Molecular formulaC33H57N11O9

CAS number129954-34-3

The overview

What is Selank?

Selank is a synthetic heptapeptide built on the natural immunopeptide tuftsin (Thr-Lys-Pro-Arg) by appending a C-terminal Pro-Gly-Pro tripeptide. The PGP tail resists cleavage by prolyl endopeptidases, markedly extending stability over native tuftsin and improving blood-brain-barrier permeability in research models. Mechanistically it is studied as a modulator of GABAergic neurotransmission - reported as a positive influence on GABA-receptor-associated signaling - alongside serotonergic effects and immunomodulatory activity on interferon and cytokine expression, reflecting its tuftsin heritage. In gene-expression studies it alters transcripts tied to GABAergic signaling and immunity. All characterization is in-vitro and preclinical neuro/immuno-signaling; no therapeutic or human-use claim is made.

In the research

Where Selank shows up

The areas researchers focus on with Selank - and why it has the science community paying attention.

GABAergic neurotransmission gene-expression models
Serotonergic and anxiolytic-pathway research
Tuftsin-derived immunomodulation (interferon/cytokine) studies

By the numbers

The facts that matter

Molecular weight751.87 g/mol

Parent peptideTuftsin (Thr-Lys-Pro-Arg) + Pro-Gly-Pro

Stability featurePGP tail resists prolyl-endopeptidase cleavage

To the molecule

Molecular specifications

Molecular formulaC33H57N11O9

Molecular weight751.87 g/mol

CAS number129954-34-3

Amino-acid sequenceThr-Lys-Pro-Arg-Pro-Gly-Pro

Sourced, not claimed

The science behind it

The peer-reviewed studies behind Selank, linked so you can read them yourself.

Volkova, A., et al. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission and Immunity in the Hippocampus. Frontiers in Pharmacology.
“Selank affected the expression of genes involved in GABAergic neurotransmission and immune response in the hippocampus.”
DOI ↗PubMed ↗

Straight answers

Questions, answered

Is Selank approved by the FDA?

No. Selank is not an FDA-approved drug. We supply it as a research-use-only reference compound, identity-verified for purity with a COA on every vial.

What class of compound is Selank?

Selank is classified as: Synthetic tuftsin-analogue heptapeptide / GABAergic and immunomodulatory neuropeptide.

What is the molecular weight of Selank?

The molecular weight of Selank is 751.87 g/mol, with a molecular formula of C33H57N11O9.

What is the CAS number for Selank?

The CAS Registry Number for Selank is 129954-34-3.

What is the amino acid sequence of Selank?

Selank has the sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro.

Go deeper

More on Selank

MechanismSelank mechanism of action: receptor binding, signal transduction, and mRead →ResearchSelank research: peer-reviewed studies, in-vitro and preclinical model cRead →ReconstitutionHow Selank is reconstituted for in-vitro laboratory research: bacteriostRead →Half-LifeSelank pharmacokinetic, stability, degradation, and storage characteristRead →SpecsSelank molecular specifications: amino-acid sequence, molecular weight, Read →FAQAnswers to common research questions about Selank: classification, strucRead →

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For in-vitro laboratory research use only. Not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. Selank is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.