Endogenous amphiphilic neuropeptide

DSIP

Also known as Delta sleep-inducing peptide · WAGGDASGE · Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Research referenceJump to specs ↓

ClassEndogenous amphiphilic neuropeptide

Molecular weight848.81 g/mol

Molecular formulaC35H48N10O15

CAS number62568-57-4

The overview

What is DSIP?

DSIP is a naturally occurring nonapeptide, first isolated from cerebral venous blood during induced sleep, studied as a modulator of stress-resistance and signaling rather than as a single-receptor ligand. In mechanistic work it is reported to interact with components of the MAPK cascade - associated with inhibition of Raf-1 activation and downstream ERK phosphorylation - and shows homology to the glucocorticoid-induced leucine-zipper (GILZ) protein. It is also studied for modulation of enkephalin–opioid-receptor interactions. The N-terminal tryptophan provides a characteristic UV-absorbance signature used in laboratory identification, and the peptide's mixed hydrophilic/hydrophobic residues give it an amphiphilic character. Reported activities are mechanistic, model-system observations (stress-protective, anti-seizure, immunomodulating) and are not statements of clinical efficacy.

In the research

Where DSIP shows up

The areas researchers focus on with DSIP - and why it has the science community paying attention.

MAPK/ERK-cascade signaling models
Stress-resistance and neuro-protective assays
Enkephalin–opioid-receptor interaction studies

By the numbers

The facts that matter

Length9 amino acids (nonapeptide)

Molecular weight848.81 g/mol

First isolated1977, from rabbit cerebral venous blood

To the molecule

Molecular specifications

Molecular formulaC35H48N10O15

Molecular weight848.81 g/mol

CAS number62568-57-4

Amino-acid sequenceTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Sourced, not claimed

The science behind it

The peer-reviewed studies behind DSIP, linked so you can read them yourself.

Graf, M. V., Kastin, A. J. (1984). Delta-sleep-inducing peptide (DSIP): a review. Neuroscience & Biobehavioral Reviews.
“DSIP has a wide spectrum of effects including sleep modulation, stress-protective, and neuroendocrine actions.”
DOI ↗PubMed ↗

Straight answers

Questions, answered

Is DSIP approved by the FDA?

No. DSIP is not an FDA-approved drug. We supply it as a research-use-only reference compound, identity-verified for purity with a COA on every vial.

What class of compound is DSIP?

DSIP is classified as: Endogenous amphiphilic neuropeptide (nonapeptide) studied in sleep, stress-resistance, and signaling models.

What is the molecular weight of DSIP?

The molecular weight of DSIP is 848.81 g/mol, with a molecular formula of C35H48N10O15.

What is the CAS number for DSIP?

The CAS Registry Number for DSIP is 62568-57-4.

What is the amino acid sequence of DSIP?

DSIP has the sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.

Go deeper

More on DSIP

MechanismDSIP mechanism of action: receptor binding, signal transduction, and molRead →ResearchDSIP research: peer-reviewed studies, in-vitro and preclinical model conRead →ReconstitutionHow DSIP is reconstituted for in-vitro laboratory research: bacteriostatRead →Half-LifeDSIP pharmacokinetic, stability, degradation, and storage characteristicRead →SpecsDSIP molecular specifications: amino-acid sequence, molecular weight, foRead →FAQAnswers to common research questions about DSIP: classification, structuRead →

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For in-vitro laboratory research use only. Not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. DSIP is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.