Hexarelin Half-Life & Stability
Part of the full Hexarelin guide - a growth-hormone-releasing peptide reference compound, identity-verified with a COA on every vial.
In brief
The source entry does not provide a numeric half-life, plasma stability constant, or degradation rate for hexarelin. What it does provide is structure-stability information; the remainder below is framed explicitly as general peptide-class handling principle, clearly separated from the one peptide-specific fact the data supports.
The detail
A closer look
01
Peptide-specific: engineered enzymatic resistance
The one stability-relevant fact in the entry is structural: two modifications - D-2-methyl-tryptophan at position 2 and D-phenylalanine at position 5 - are described as conferring resistance to enzymatic degradation (in addition to shaping receptor affinity). D-amino-acid substitutions of this kind are a recognized strategy for making a peptide a poorer substrate for proteases. The entry attributes hexarelin's degradation resistance specifically to these two D-residues; it does not, however, state a half-life value, so no PK number should be inferred from this fact.
02
General peptide-class storage and stability principles
Because no peptide-specific PK data is given, the following are general lyophilized-peptide handling principles, not hexarelin measurements. Lyophilized peptides are typically most stable as the dry solid and are generally held frozen for long-term storage. Once reconstituted into aqueous solvent, peptides are generally less stable than in the dry state and are commonly kept refrigerated for short-term working use, with aliquoting used to avoid repeated freeze-thaw cycles that can accelerate degradation. Protection from light, heat, and repeated temperature swings is standard practice. These apply to peptides as a class and are stated here as general principle rather than as values drawn from the hexarelin entry.
03
What the data does not establish
To stay strictly within the source: there is no provided in-vitro or in-vivo half-life, no clearance figure, no solution-stability shelf-life, and no degradation-pathway detail beyond the qualitative note that the D-2-methyl-Trp(2) and D-Phe(5) substitutions resist enzymatic degradation. Any quantitative stability or PK characterization would require data not present in this entry.
The fine print: products are sold for laboratory research use only and are not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. Hexarelin is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.