Thymosin Alpha-1 Specs: Sequence, MW & CAS
Part of the full Thymosin Alpha-1 guide - a immunomodulatory thymic peptide reference compound, identity-verified with a COA on every vial.
In brief
The physicochemical identifiers in the entry define what this molecule is and constrain how it behaves at the bench. Thymosin alpha-1 is specified as a 28-amino-acid N-acetylated peptide with sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH, a molecular weight of 3108.32 g/mol, a molecular formula of C129H215N33O55, and CAS number 62304-98-7. The sections below explain what these identifiers mean and what structure-function notes follow from them, using only the entry's data.
To the molecule
Molecular specifications
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OHThe detail
A closer look
01
Sequence, length, and the acetylation/charge profile
The peptide is 28 residues long (length attributed in the entry to Cayman / CPC Scientific), placing it well above the small-oligopeptide range. The N-terminus carries an acetyl cap (the leading Ac-Ser-) and the C-terminus is the free acid (-OH on the terminal Asn), which together fix the chemistry of both ends. The sequence is conspicuously rich in acidic and basic residues, with multiple glutamate (Glu) and aspartate (Asp) residues alongside several lysines (Lys), giving it a highly charged, hydrophilic character. This composition is consistent with its behavior as a soluble immunomodulatory peptide that engages cell-surface and endosomal receptor machinery rather than partitioning into membranes.
02
Molecular weight, formula, and CAS as identity and quantitation anchors
The molecular weight of 3108.32 g/mol (attributed to ChemicalBook) and molecular formula C129H215N33O55 are the quantitation anchors for the molecule: the molecular weight is the exact conversion factor used to translate a reconstituted mass-per-volume concentration into molarity for assay work, and the formula fixes the elemental composition for analytical confirmation. The CAS number 62304-98-7 is the unique registry identifier that disambiguates this specific peptide for sourcing and record-keeping. Together these three identifiers let an investigator confirm material identity and compute precise molar stock concentrations.
03
Structure-function: no disulfide bonds and the TLR-modulator role
A defining structure-function note from the entry is that the linear sequence carries no cysteines and no disulfide bonds. The functional consequence is twofold: there is no disulfide-stabilized tertiary fold to preserve, and there is no oxidation-prone thiol chemistry to manage during reconstitution and storage. Functionally, the entry assigns the molecule to the immunomodulatory thymic-peptide class acting as a TLR2/TLR9 signaling modulator; its charged, cysteine-free, acetylated linear structure is the chemical basis on which the documented in-vitro dendritic-cell, T-cell, and innate-immune signaling activities are read out.
The fine print: products are sold for laboratory research use only and are not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. Thymosin Alpha-1 is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.