Semax Specs: Sequence, MW & CAS
Part of the full Semax guide - a synthetic melanocortin reference compound, identity-verified with a COA on every vial.
In brief
The molecular specification of Semax fixes its identity precisely and explains much of its reported behavior. It is a heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro (one-letter handling aside, written H-Met-Glu-His-Phe-Pro-Gly-Pro-OH), an average molecular weight of 813.92 g/mol as the free base, the molecular formula C37H51N9O10S, and CAS Registry Number 80714-61-0. Each of these descriptors carries structure-function meaning rather than being a bare label: the sequence reveals the ACTH-fragment origin and the stability-conferring tail, the formula and weight pin down the exact atomic composition for analytical confirmation, and the CAS number provides an unambiguous registry identity across suppliers and databases. This section unpacks what those specifications mean and how they connect to the peptide's documented binding and stability properties, so a researcher can read the spec card as mechanism rather than as inert catalog data. All values are taken directly from the provided entry.
To the molecule
Molecular specifications
Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP); H-Met-Glu-His-Phe-Pro-Gly-Pro-OHThe detail
A closer look
01
Sequence as structure-function blueprint
The sequence Met-Glu-His-Phe-Pro-Gly-Pro is itself the design rationale. The first four residues, Met-Glu-His-Phe, are the ACTH(4-7) fragment, the portion of adrenocorticotropic hormone retained to provide the melanocortin-derived recognition core; the data notes that because the N-terminal corticotropic residues of full ACTH are absent, Semax is described as devoid of classical adrenal-stimulating activity. The final three residues, Pro-Gly-Pro, are a deliberate C-terminal addition whose function is enzymatic protection: the proline-rich tail shields the peptide from aminopeptidase cleavage, increasing metabolic stability over native ACTH(4-10). Thus the seven-residue chain encodes both halves of the molecule's identity, a melanocortin-fragment binding head and a stabilizing tail. The histidine and methionine residues also carry chemical notes: His contributes to recognition, while the sulfur-bearing Met (the S in the formula) is the site relevant to oxidation considerations during handling.
02
Formula, mass, and CAS identity for analytical confirmation
The molecular formula C37H51N9O10S and average molecular weight of 813.92 g/mol (free base) together specify the exact atomic makeup used to confirm identity and purity analytically. The single sulfur atom corresponds to the methionine residue; the nine nitrogens reflect the peptide backbone amides plus side-chain nitrogens from histidine. A defined molecular weight is also the basis for converting reconstituted mass concentrations into molar units for assays. CAS Registry Number 80714-61-0 provides a unique, supplier-independent identifier that ties the entry to reference databases (the data cites PubChem CID 9811102, ChemicalBook, and Cayman Chemical for these descriptors). For a researcher, the practical value of this spec block is verification: matching a certificate of analysis, mass-spectrometric measurement, and CAS lookup against these listed values confirms that received material is the intended ACTH(4-10)-derived heptapeptide and not a mislabeled analog.
The fine print: products are sold for laboratory research use only and are not for human or animal consumption. Bodily introduction into humans or animals is strictly prohibited by law. Semax is not a drug and is not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the FDA.